Tolvaptan for the Treatment of Refractory Ascites
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چکیده
منابع مشابه
Tolvaptan for the Treatment of Refractory Ascites
To the Editor: The findings from a Japanese phase 3 trial revealed that tolvaptan (Otsuka Pharmaceutical, Osaka, Japan), a non-peptide antagonist of the vasopressin type 2 receptor, is effective in the treatment of refractory ascites in cirrhotic patients. Although this agent is now widely used in clinical practice, few reports have so far been published regarding its real-world efficacy. The r...
متن کاملCases with Refractory Ascites and a Delayed Response to Tolvaptan
The patient was a 67-year-old female with liver cirrhosis due to hepatitis C. She was administered furosemide at 20 mg/day and spironolactone at 25 mg/day, but the ascites did not improve. Despite the additional administration of tolvaptan at 3.75 mg/day, the response to ascites was still poor. While the dose of tolvaptan was thereafter increased to 7.5 mg/day on the 7th hospital day, the ascit...
متن کاملRe-response to tolvaptan after furosemide dose reduction in a patient with refractory ascites
Tolvaptan is a new drug used for treating ascites induced by liver cirrhosis, and it is covered by health insurance in Japan. In the present report, we describe the case of a 74-year-old man with type C liver cirrhosis and refractory ascites. He was receiving furosemide and spironolactone daily, but still required repeat puncture for ascites removal. Administration of tolvaptan (3.75 mg/day) wa...
متن کاملNutritional status and long-term prognosis in patients with refractory hepatic ascites treated with tolvaptan
Objective: We evaluated whether nutritional status and long-term prognosis of patients with refractory hepatic ascites improved after treatment with tolvaptan. Methods: We retrospectively studied data for a total of 50 patients with hepatic ascites treated with tolvaptan from April 2011 to January 2016. Bloatedness was assessed by using the Japanese version of the support team assessment schedu...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2016
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.55.7556